|
KMID : 1144820210270040334
|
|
대한의생명과학회지
2021 Volume.27 No. 4 p.334 ~ p.339
|
|
|
Effects of Inhibiting Glycoprotein MUC5AC by Seaweed Ecklonia cava Extract in human Airway Epithelial Cells
|
|
Lee Sung-Gyu
Kwon Sang-Oh
|
|
|
Abstract
|
|
|
|
In the present study, antioxidant and MUC5AC mucin inhibition activities were measured in Ecklonia cava (E. cava) extract. The E. cava extract showed the total polyphenol and flavonoid contents of 607.40±19.44 μg GAE/mg and 13.33±5.28 μg QE/mg, respectively. The free radical scavenging activity of E. cava extract was high in the DPPH radical scavenging activity (RC50 7.08 μg/mL) and ABTS+ radical scavenging activity (RC50 4.74 μg/mL). Also, we investigated whether E. cava extract affects airway MUC5AC mucin gene expression, production and secretion induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells. Cells were treated with E. cava extract and then stimulated with PMA for 24 h. The E. cava extract inhibited the gene expression of MUC5AC mucin from NCI-H292 cells. This result suggests that E. cava extract can inhibit the gene expression of mucin induced by PMA through directly acting on airway epithelial cells.
|
|
|
KEYWORD
|
|
|
Ecklonia cava, MUC5AC, NCI-H292, PMA, Seaweed
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|